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In the 12 months after an index event, 1.5% of patients with nonfatal MI and 0.5% with nonfatal stroke initiated a GLP-1, the two most common being semaglutide (Wegovy, Novo Nordisk) and liraglutide, followed by dulaglutide (Trulicity, Eli Lilly)
It is FDA-approved as Mounjaro (type 2 diabetes, 2022) and Zepbound (obesity, 2023)
Hypoglycemia (RR 353, 95% CI 199 to 627) and total adverse reactions (RR 114, 95% CI 110 to 119) occurred more frequently in the daily group than that in the weekly group ( Table S19 )
It remains an investigational drug studied primarily for obesity and type 2 diabetes
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