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In the SURMOUNT-1 obesity trial, tirzepatide produced mean weight reductions of roughly 1521% depending on dose over 72 weeks ( Jastreboff et al., NEJM 2022
It works by upregulating growth factor expression, promoting angiogenesis, and modulating the nitric oxide system
The sterile solution water for injection plus 0.9% benzyl alcohol inhibits bacterial growth without sterilizing the solution outright, which is exactly the property you want when a single vial may be drawn from multiple times over days or weeks
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