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Common Side Effects Abdominal pain Constipation or diarrhea Nausea or vomiting Practical tip: Start low, take it with meals, and increase gradually only if you tolerate it
Most common adverse events at all doses: Nausea (15-30%, dose-related) Vomiting (5-15%) Decreased appetite (~20%) Constipation (5-12%) Cagrilintide-specific notes: A 2025 Bayesian network meta-analysis of incretin-based therapies reported cagrilintide had one of the lowest GI odds ratios across the studied compound class
Headaches: Some users may experience headaches after using the nasal spray
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