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Metformin has separately shown wound healing benefits: a 2021 randomized trial (N=108) of topical metformin on diabetic foot ulcers found a 52% complete healing rate at 12 weeks versus 31% with standard care alone (P=0.02) [11]
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When estrogen levels begin the gradual perimenopause transition in the mid-to-late 30s, GH pulse amplitude and frequency decline alongside it
Nutrient absorption remains challenging even with a healthy diet
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