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Taken together, these studies establish potentially converging disease mechanisms in ALS and spinal muscular atrophy, with ALS-causative mutants acquiring properties representing both gain (dysregulation of SMN) and loss (reduced RNA processing mediated by U1-snRNP) of function
This creates a clean concentration of 10 mg/mL, which makes every subsequent syringe measurement simple, accurate, and impossible to mess up
The interplay of glucagon-like peptide-1 receptor trafficking and signalling in pancreatic beta cells
Disruptions in rhythm accelerate cellular aging, impair immune surveillance, and increase disease risk across all major systems of the body
