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Less fluid in the gut means: Less lubrication Firmer stools Slower transit Dehydration also concentrates electrolytes, such as calcium, which can have constipating effects
Take in divided doses of 500mg or less for optimal absorption
perhaps to protect against acute increases in the plasma calcium concentration, and a subtle and potentially more important long-term effect to regulate bone formation
In mice treated for 4 weeks with SLU-PP-332 (Billon 2023, 10-30 mg/kg orally or IP): - Skeletal muscle : increased mitochondrial content (mitochondrial/nuclear DNA +30-50%), slow-oxidative fiber shift, increased beta-oxidation enzymatic capacity, treadmill endurance increase +45 to +70%
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