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generally considered compatible Interaction type / Pharmacodynamic (additive glucose-lowering) plus minor pharmacokinetic (absorption) Timing recommendation / Separate by at least 2 hours to minimize any absorption overlap Magnesium and insulin sensitivity / Low serum magnesium independently worsens insulin resistance Prevalence of low magnesium in T2D / Up to 48% of people with type 2 diabetes have hypomagnesemia Best-studied magnesium form / Magnesium glycinate or magnesium oxide used in most diabetes trials Key monitoring metric / Serum magnesium (reference range 1.7 to 2.3 mg/dL) Relevant FDA label note / Metformin label does not list magnesium as a contraindicated supplement Metformin and B12 / Long-term metformin separately depletes B12, not magnesium directly Who needs closest monitoring / People on PPIs or loop diuretics alongside metformin The Short Answer: Magnesium and Metformin Are Compatible Taking magnesium alongside metformin does not produce a dangerous drug-supplement interaction

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There are also regulatory realities: both peptides are prohibited in sport, and BPC-157s status is set out plainly by USADA