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diabetes-nave patients have no prior activity for metformin, GLP-1s, or other diabetes medicines such as insulins, DPP-4s, SGLT-2s, etc

John Eng at the VA Medical Center in the Bronx discovered exendin-4, a peptide in Gila monster venom that mimicked GLP-1 but lasted hours instead of minutes

Some evidence suggests the combined hormone effects may lead to better weight loss results than than those taking semaglutide, although research comparing the two drugs head-to-head is still underway

miRNAs are small (2023-nucleotides), endogenous, single-stranded noncoding RNAs that regulate gene expression by pairing to sequence-specific binding sites in mRNAs to direct post-transcriptional repression and consequent inhibition of protein translation or degradation of the mRNA targets [179,180,181]