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In particular, tell your provider if you have or have a past history of: Thyroid cancer Type 1 or type 2 diabetes Gastrointestinal disease Pancreatitis Liver disease Kidney disease Diabetic retinopathy Tell your provider if you are pregnant, planning to become pregnant, or breastfeeding

Spermidine and spermine can exert bone protective effects , where they prevent ovariectomy-induced bone loss by inhibiting osteoclast differentiation and maturation without impairing cell viability