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The many pathways identified include: Dopaminergic signaling Glutamatergic signaling Leptin-mediated pathways PI3K-AKT signaling Histamine signaling Insulin secretion and lipid metabolism These mechanisms influence appetite regulation, reward processing, energy balance, glucose homeostasis, and metabolic control

The clinical significance of biased dual GIPRAs and GLP-1RAs has not yet been assessed due to the limited existence of such clinically available drugs