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It appears to interact with key biological systems, such as the nitric oxide pathway and antioxidant defenses, which may explain its broad therapeutic effects
Cleavage of SDF-1 by DPP-4 results in loss of activity (65), and consistent with this, DPP-4 inhibition in humans has been associated with enhancement of some effects which are associated with SDF-1 [increased levels of circulating endothelial progenitor cells (66) and increased distal tube sodium excretion (64)]
Aqueous deficiency arises from inadequate tear production, frequently resulting from disorders such as Sjgren's syndrome or failure of the lacrimal glands
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