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A recent study has shown that the genetic diagnosis of PWS and the start of GH therapy occur earlier in patients with a del15q than in those with mUPD and an imprinting center defect (ID) ( Among patients with mUPD, GHD is more common and severe than patients with a del15q (116)
Metformin, the prescription medicine for type 2 diabetes, may have similar features to berberine supplements regarding glucose metabolism
117 Additionally, MAPK pathway hyperactivation, driven by NF1 loss, induces ligand-independent ER activation through persistent RAS signaling, contributing to endocrine resistance
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