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As a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, Mounjaro works by enhancing insulin secretion when blood glucose levels are elevated, suppressing glucagon release, slowing gastric emptying, and reducing appetite
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This was achieved by inhibiting bone resorption through an increase in the OPG/RANKL ratio and promoting bone formation by enhancing the expression of osteoblast-specific transcription factors
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