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These medicines work by mimicking the action of the naturally occurring hormone GLP-1, which is released from the intestine in response to food intake
J Toxicol Environ Health B Crit Rev 26:307341 Shaher SAA, Mihailescu DF, Amuzescu B (2023) Aspartame safety as a food sweetener and related health hazards
If a given dose level causes persistent nausea or vomiting that does not respond to dietary adjustments, the Endocrine Society's 2024 pharmacotherapy guidelines allow the prescriber to extend that step by an additional four weeks before escalating [2]
But more recent research suggests that the drug slashes the risk of kidney failure and death in people who have type 2 diabetes and chronic kidney disease
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