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Prevention desensitization: Cycle 5 days ON / 2 days OFF: Maintains sensitivity Step-up dosage Avoid starting at maximum dose Rotation Some protocols alternate weeks of treatment/rest Monitoring Measure IGF-1 every 4 weeks (indirect indicator) Studies up to 24 weeks without significant desensitization with the 5/2 protocol
No significant sex- or weight-based risks were noted for liraglutide or tirzepatide
[Epub ahead of print] PMID: 30322710 Spectral-Domain OCT: Helping the Clinician Diagnose Glaucoma: A Report by the American Academy of Ophthalmology
If semaglutide gives you adequate appetite control and steady weight loss with good tolerability, switching may not provide meaningful additional benefit
