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J Biol Chem 236:14251428 Bannai S, Tsukeda H, Okumura H (1977) Effect of antioxidants on cultured human diploid fibroblasts exposed to cystine-free medium

In two studies, BVT-A suppressed GH induction of IGF1 expression in hepatocytes in vitro and reduced GH stimulation of IGF1 secretion and body weight in hypophysectomized rats

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This process is exacerbated by smoking, pollution, exposure to UV or ionizing radiation, eating fried foods or those cooked at high temperatures, as well as engaging in high-intensity exercise (12)

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