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The peptide also increases integrin expression in basal keratinocytes at concentrations of 0.1-10 micromolar, enhancing p63 positivity, a transcription factor that maintains stem cell characteristics

Cysteine degradation and energy metabolism Although the role of cysteine degradation in cancer development has predominantly been explored regarding H 2 S production, the usefulness of cysteine as a carbon source is also evident along its catabolic pathways, as its degradation gives rise to other organic compounds relevant for carbon and energy metabolism (Fig

Moreover, CHIP was found to be common in patients with dyskeratosis congenita, a disease resulting from mutation in TL maintenance genes, including those that encode telomerase subunits and thereby causing critically short telomeres

Diseases in the final section of the ileum (part of the small intestine), e.g