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Cysteine is a derivative of cystine which is brought into the cell via a transmembrane protein antiporter named system x c ( In addition to this canonical pathway, alternative antioxidant systems also modulate ferroptosis, including the ubiquinone-10 (CoQ10) pathway and the tetrahydrobiopterin (BH4) pathway ( Ferroptosis can be initiated through two major pathwaysthe extrinsic pathway and the intrinsic pathway