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GLP-1R agonists present a promising therapeutic option for HFpEF by targeting endothelial dysfunction and other pathophysiological mechanisms
In summary, amino acid metabolism precisely regulates the ferroptotic process through several distinct pathways, such as the Xc-/GSH/GPX4, FSP1/DHODH/CoQ, GCH1/BH4, NRF2/SLC7A11/GPX4, and AMPK (Figure 4)
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