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When cerebrovascular illness other than heart failure or renal disease predominates, GLP1RAs are suggested over SLGT2 inhibitors

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CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) Novo Nordisk submitted a New Drug Application to the FDA for CagriSema for chronic weight management on 18 December 2025

However, CJC-1295 (especially the DAC version) can cause sustained elevation in IGF-1, whichif mismanagedmay increase the risk of: Insulin resistance Carpal tunnel syndrome Soft tissue growth (in rare, prolonged cases) Pituitary overstimulation That said, these issues are more often associated with excessive dosing or continuous high-frequency use