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Increased Energy Expenditure: GLP-1 RAs may activate sympathetic pathways in the hypothalamus (specifically the dorsomedial and ventromedial nuclei) that increase thermogenic activity in brown adipose tissue (BAT), contributing to increased energy expenditure and weight loss
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Inhaled exosomes or lipid nanoparticles (LNPs) functionalized with ligands for alveolar epithelial cell or macrophage-specific receptors (e.g., CD44 for macrophages) represent a promising strategy
Enter Retatrutide Retatrutide is the first triple agonist targeting 3 metabolic receptors at once: GLP-1: Enhances insulin, reduces appetite, slows digestion GIP: Boosts insulin, improves lipid metabolism GCGR: Increases energy expenditure, burns fat GLP-1 activation stimulates insulin secretion from pancreatic -cells, reduces appetite through central pathways, and slows gastric emptying to reduce glucose spikes
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