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W.SonnewaldS.et al (2017)
In accordance with this, it is worth highlighting the study conducted by Clark et al.22, including 995 very-low-weight newborns (VLWNBs), which demonstrated that adding L-carnitine to the PN solution generated an increase in plasma levels without any improvement in the lipid profile (measured as free carnitine, acylcarnitine and free fatty acids), weight gain during the first 28 days of life, or specific mortality or morbidity
In our model, depletion of Hypoxia-Inducible Factor 1 alpha (HIF-1) impaired the effects of Exendin-4 on glucose metabolism, while pharmacological inhibition of Phosphoinositide 3-kinase (PI3K) or mTOR completely abolished such effects
YanSWangKWangXOuAWangFWuLet al
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