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Hypoxic conditions can also lead to a phenomenon known as DPP-4 shedding whereby transmembrane DPP-4 is cleaved from the membrane and released into the circulation in a soluble form

When combined with anti-PD-1 therapy, TCFI significantly increased tumor-infiltrating CD8 + T cells and IFN- secretion, achieving robust suppression of primary tumors, lung metastases, and recurrence