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In real-world observations, individuals on GLP-1 therapies often fall below dietary benchmarks for: 3,5 Microminerals : magnesium, potassium, calcium, iron, and zinc Vitamins : D, A, E, K, B12, B1 (thiamine), and folate Macronutrients : protein and fiber Phytonutrients : including carotenoids and flavonoids Gastrointestinal effectsincluding nausea, bloating, early satiety, and evolving food aversionsfurther constrict intake variety and volume, amplifying the risk
Laboratory investigations have reported measurable changes in nitric oxide related signaling markers, endothelial migration assays, fibroblast gene expression profiles, and cytoskeletal reorganization markers in cell culture and animal models
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