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Mechanistically, alterations in gut microbial metabolites such as SCFAs could affect the integrity of the BBB, induce systemic endotoxemia, and activate microglia so as to impact disease progression

The continuous systemic inflammation generated by this vascular damage further depletes the body's already compromised antioxidant reserves, perpetuating the cycle of chronic illness and making recovery incredibly difficult without targeted biochemical intervention

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Glutathione itself is available as a compounded pharmaceutical ingredient, and licensed compounding pharmacies legally produce it for clinical use