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Studies Linking GLP-1 Medications to NAION Several peer-reviewed studies have confirmed an increased risk of NAION in patients taking GLP-1 drugs: Harvard Medical School & Mass General Brigham Study (JAMA Ophthalmology, 2024) 9% of diabetic patients taking semaglutide developed NAION, compared to 1.8% on other diabetes drugs (a 4-fold increased risk)
Each receptor limb contributes a distinct downstream effect in preclinical models, and their concurrent activation is hypothesised to produce additive or synergistic metabolic signalling
Other formulations like Ozempic, Mounjaro, and Rybelsus are approved for diabetes but not specifically for weight management
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And because weed-smokers inhale more deeply and hold the smoke in longer, theyre exposed to more tar per breath than cigarette smokers
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