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ROS Overproduction: The Initiating Driver Hyperglycaemia activates multiple simultaneous ROS sources, including mitochondrial uncoupling, NADPH oxidase isoforms NOX2 and NOX4, and xanthine oxidase upregulation

Because we and others have shown that mitochondrial respiration is required for the maintenance of T H 1 cell function 41 , these results offer a potential explanation for defective adaptive immune responses in severe COVID-19

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