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Well-characterized mechanisms of action can be invaluable for clinicians making critical treatment decisions and can greatly inform drug design and synthesis
Pharmaceuticals, 18(2), 185
FOXO4-DRI is a roughly 5.4 kDa, strongly cationic TAT-fusion peptide, and cationic peptides tend to bind extracellular matrix at the injection site, so subQ delivery could plausibly be substantially lower than IV
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