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Inflammation in the GI tract often leads to lower stomach acid which impairs the absorption of B12
doi:10.3164/jcbn.2.1
However, as oxidative stress increases, the permeability of this barrier increases, and free radicals can cross the barrier
Organ and tissue growth concerns Because IGF-1 signaling affects cellular growth and proliferation throughout the body and not exclusively in skeletal muscle, there is concern that long-term use of IGF-1 could result in increased growth of other tissues/organs in the body
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