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347 In breast cancer, Pseudomonas aeruginosa secretes the quorum-sensing molecule N-(3-oxo-dodecanoyl)-L-homoserine lactone (3OC), which induces ligand-independent dimerization of TRII, aberrantly activating TGF- signaling
Freeze-thaw cycles may damage the peptide
Supported by: US Department of the Army grant DAMD17-98-1-8621 and the Office of Research and Development, Medical Research Service, Department of Veterans Affairs (GWR), Hawaii Community Foundation Grant 20071373 (FPB), NIH RO1 NS40302 (MJB), NIH R24 DA027318 (MJB/FPB), NIH U01 AG019349 (LRW), and NIH G12 RR003061 which supports the JABSOM histology/imaging core facility
Acknowledgements The authors are supported by National Institute of Diabetes and Digestive and Kidney Disease grants R01DK61931 and R01DK68271 (J.R.T.), U.S
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