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In human AML stem cells, BCAT1 is overexpressed, and the BCAA pathway is activated by the low levels of -KG, displaying a DNA hypermethylation phenotype similar to IDH mutant-positive cancers (Raffel et al., 2017)
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Allosteric (off active site) activators were reported in the literature as early as the mid-2000s, but they had poor potency, poor pharmacokinetics, species-selective activity (human but not rodent), and none made it close to the clinic
Without adequate protein, the body may lose muscle along with fat during weight loss
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