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However, unlike branded medicines, these compounds are not FDA-approved because no clinical trials have tested their safety and effectiveness
A statistically significant overall treatment effect at each timepoint was noted, implying bone preservation for all active treatment groups at all timepoints, as opposed to bone loss for placebo at all timepoints
This can be seen, he said, in the use of the ICH E9 (R1) addendum on estimands and sensitivity analysis in clinical trials, with companies including Novo Nordisk and Lilly employing this framework
Herrera-Arozamena, C
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