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In the search for this prophesised molecule, Dr Joel Habener and his team at Massachusetts General Hospital decided in the late 1970s to study glucagon, another hormone produced by the pancreas that has an opposite action to insulin and increases blood glucose levels
A missense mutation (R120G) in B-crystallin leads to abnormal aggregation of both desmin and B-crystallin, resulting in severe cardiomyopathy known as desminopathy
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