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Importantly, several studies indicate that these metabolites may retain partial biological activity, suggesting that in vivo effects attributed to HTY may arise from a combination of parent compound and metabolite-mediated mechanisms [56]

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Recently, we have demonstrated that a short-echo time (TE) spin-echo full-intensity acquisition localized single voxel spectroscopy (SPECIAL) sequence could robustly assess Gln levels in the brain, which correlated with plasma levels 20

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