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However, the great complexity of the hypothalamus, in terms of the large number of existing neuronal types that can release very different compounds, suggests that more neurotransmitters with the capacity to act on the SS and, consequently, on the hypothalamic-somatotropic axis can still be identified, although, logically, their actions will always be more secondary than those of the factors that have been described in this chapter

Janumet has a black box warning for a rare but serious condition called lactic acidosis, which is caused by the metformin in the medication