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The advantage appears to come from tirzepatide's dual mechanism (GIP plus GLP-1) versus semaglutide's single mechanism (GLP-1 only)

Dietitians recommend that in order to optimize protein usage, an adult weighing 150 pounds should consume between 80 to 110 grams of protein spread evenly over three to four meals per day

Patients should understand that weight maintenance strategies will be important, as evidence from clinical trials suggests that discontinuation leads to weight regain in most individuals

While it is not FDA-approved as a final product, it is prepared by specialized pharmacies to help patients access treatment during branded medication shortages