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The newly improved glucagon-dependent insulinotropic polypeptide/GLP-1 RAs result in more than 20% weight loss in a recent clinical trial ( GLP-1RAs may be appropriate in patients with a BMI of 25 or greater and does require a rigorous prospective study to further characterize the role of GLP-1RAs in the treatment of lymphedema

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Basic and translational research has identified numerous biological mechanisms genetic susceptibility, appetite-regulation pathways, neuroendocrine processes, metabolic adaptation that contribute to weight gain and impede its loss

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