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In rats, GCLC has a Km for glutamate that is about 10-fold higher than that of the GCL holoenzyme, which is higher than the cellular glutamate concentration in most tissues GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by glutathione (GSH) (Ki = 2.3 mM) which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1]
Mechanism of Action at Cellular Level Angiogenic Pathway Activation One of the most extensively characterized mechanisms of BPC-157 involves its pro-angiogenic effects mediated through the vascular endothelial growth factor receptor 2 (VEGFR2) signaling system
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AOD9604 is a research compound sold for laboratory and research use only
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