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Both hit amylin biology
In the stomach, the cells lining the stomach produce a protein called intrinsic factor
It suppresses glucagon secretion from the pancreas, which prevents your liver from dumping excess glucose into your bloodstream after meals
In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation
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