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Important Safety Information for Foundayo (orforglipron) tablet Warning: Risk of Thyroid C-Cell Tumors In rats and mice, certain GLP-1 medications caused thyroid C-cell tumors

Quantification of lipogenesis gene expression To quantify gene expression, we used the Pure Link RNA Mini kit (12183025, Invitrogen, USA), Hilden, Germany) to extract total RNA from untreated and treated HepG2 cells and used High-Capacity cDNA Reverse Transcription kit (4368813, Applied Biosystems, Foster City, CA, USA) and 2 g total RNA to prepare cDNA

Nikon A1R confocal microscope (Nikon, Japan) was applied to generate 3D rendered videos