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Dimethyl fumarate (DMF), an FDA-approved drug prescribed for the treatment of multiple sclerosis (55, 56), activates NRF2 by disrupting its interaction with KEAP1 ( Figure 7A ), allowing NRF2 to translocate to the nucleus and become transcriptionally active (5557)
Histamine release is the associated mechanism following acetylcysteine adverse reaction in man
Cheng et al
Reversible and Irreversible Protein Glutathionylation: Biological and Clinical Aspects
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