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Affected individuals display a spectrum of disease severity corresponding to the degree of reduction in G6PD activity, which is determined by the specific G6PD variant alleles present 7,8,9
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The proposed structural basis for specificity is the sequence-selective DNA-binding idea described above: different peptides, by binding different DNA motifs, would preferentially modulate genes that are transcriptionally active in different tissues
This may happen if they have a strong allergy to something in the approved prescription drugs
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