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FOXO4-DRI is a large peptide (~5382 Da, 48 amino acids) with a critical structural modification: the D-Retro-Inverso (DRI) design uses D-amino acids in reversed sequence to confer protease resistance while maintaining the 3D spatial arrangement needed for target binding
Collagen synthesis requires specific amino acids including glycine, proline, and hydroxyproline
However, the efficiency of GSH redox system declines with age, predisposing the RPE to increased oxidative-stress-mediated damage 15,16
Rheumatology (Oxford) 49, 16181631 (2010)
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