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This exorbitant cost makes GLP-1RAs inaccessible to most, and it likely wont be changing soon
A 2019 pharmacokinetic sub-study showed that liraglutide 1.8 mg delayed gastric emptying of a solid meal by approximately 30 minutes on average (Diabetes, Obesity and Metabolism) [5]
Interactions between leptin and exendin-4, a glucagon-like peptide-1 agonist, in the regulation of food intake in the rat
But lesser amounts didn't trigger negative effects, which is why the scientists recommended a maximum single dose of 0.4 grams per kilogram of body weight and a maximum daily total of 0.9 grams per kilogram of bodyweight
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