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Two structural modifications (C18 fatty acid chain enabling albumin binding, and a substitution at position 8 conferring DPP-4 resistance) extend its half-life to approximately 1 week, enabling once-weekly subcutaneous dosing

This process is controlled by the phenoloxidase (PO) cascade, which is initiated when a pathogen associated molecular pattern (PAMP) binds to its pattern recognition receptor (PRR) eliciting a serine protease cascade

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