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Description

The compound is a cyclic lactam analogue of -MSH that has an amino sequence named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2)

10.1021/acsmedchemlett.1c00500 47 HumphreyJ

SNAC works by creating a temporary, localized pH-buffering effect that allows semaglutide to pass directly through the stomach lining into the bloodstream, protecting it from enzymatic degradation along the way