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mediated through MC4R Cardiovascular : Reports of blood pressure changes, particularly with higher doses Erections : Spontaneous erections in male users, particularly during initial dosing Injection site : Reactions common with subcutaneous administration Regulatory warnings : TGA (Australia), EMA, and other agencies have issued warnings about unregulated MT-2 use PT-141 Side Effects# PT-141's side effect profile is better characterized through Phase 3 data: Nausea : Most common adverse event (~40% of patients in trials)