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Ligand specificity GLP-2 and GLP-1 share high sequence similarity (69.7%) and have almost identical residues in two regions: the N-terminus (first six residues in GLP-2) that penetrates into the TMD core, and the C-terminus (residues 1833) that is recognized by the ECD and ECL1 of the receptor
[3] That clean receptor profile is the reason Ipamorelin, rather than an older GHRP, is the ghrelin-mimetic component most often paired with a GHRH analog in research blends
10.1007/s10522-015-9578-8 Biogerontology
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