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doi:10.1093/ajcn/83.5.1097
Going from 2 mg directly to 8 mg, or from 4 mg to 12 mg, dramatically increases the risk of severe gastrointestinal events and potential complications
The active ingredient belongs to the class of GLP-1 receptor agonists
The lean mass losses observed are broadly consistent with what you'd expect from equivalent caloric restriction, though the researchers noted that GLP-1 medicines have a distinct effect on the muscle proteome compared to calorie restriction alone
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