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Body aches most commonly appear early, usually in the initial phase of Week 1 to 4 after starting or increasing the dose, and many patients show improvement in the adaptation phase by Week 4 to 8

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Since the two different pharmacological activities of the peptide antibody fusion molecule cannot be titrated separately, precise adjustment of the potency at GLP-1R was required to achieve effective and safe GLP-1 activity at doses likely able to suppress PCSK9

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